William K. Oh, MD
Chief, Division of Hematology and Medical Oncology
Deputy Director, The Tisch Cancer Institute
Professor of Medicine and Urology
Ezra M. Greenspan, MD Professor in Clinical Cancer Therapeutics
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Ajai Chari, MD
Associate Professor of Medicine
Director Clinical Research, Multiple Myeloma Program
Associate Medical Director, Tisch Cancer Institute Clinical Trials Office
Icahn School of Medicine at Mount Sinai
New York, NY, USA
This edition first published 2019
© 2019 John Wiley & Sons Ltd
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Library of Congress Cataloging-in-Publication Data
Names: Oh, William K., editor. | Chari, Ajai, editor.
Title: Mount Sinai expert guides. Oncology / [edited by] William K. Oh, Ajai Chari.
Other titles: Oncology
Description: Hoboken, NJ : Wiley, 2019. | Includes bibliographical references and index. |
Identifiers: LCCN 2019015625 (print) | LCCN 2019017014 (ebook) | ISBN 9781119189572 (Adobe PDF) | ISBN 9781119189589 (ePub) | ISBN 9781119189558 (pbk.)
Subjects: | MESH: Neoplasms | Medical Oncology–methods | Handbook
Classification: LCC RC263 (ebook) | LCC RC263 (print) | NLM QZ 39 | DDC 616.99/4–dc23
LC record available at https://lccn.loc.gov/2019015625
Cover image: © Raycat/Getty Images
Cover design by Wiley
Raquela Adelsberg, MS, RD, CDN
Clinical Nutrition Coordinator
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Celina Ang MD
Associate Professor
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Kenneth L. Angelino MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Daniel Aruch MD
Oncologist
Virginia Oncologist Associates
Virginia Beach, VA, USA
Kevin Barley MD
Hematologist
Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Meredith K. Bartelstein MD
Fellow, Orthopedic Oncology
Memorial Sloan Kettering Cancer Center
New York, NY, USA
Surabhi Batra MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Ann Marie Beddoe MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Adam F. Binder MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Joshua D. Brody
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Rebecca M. Brown MD, PhD
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Corazon B. Cajulis DNP, RN, ANP-BC
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Ajai Chari MD
Associate Professor of Medicine
Director Clinical Research, Multiple Myeloma Program
Associate Medical Director, Tisch Cancer Institute Clinical Trials Office
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Carmel J. Cohen MD
Professor Emeritus
Obstetrics, Gynecology and Reproductive Science
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Seth M. Cohen MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Idoia Corcuera-Solano MD
Translational and Molecular Imaging Institute
Department of Radiology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Caroline Cromwell MD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Bruce E. Culliney MD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Jaclyn C. Davis MD
Clinical Development Medical Director
Novartis Pharmaceuticals Corporation
East Hanover, NJ, USA
Peter Dottino MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Ashley J. D'Silva MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Ronald D. Ennis MD
Professor and Vice Chair of Network Integration and Quality
Department of Radiation Oncology
Cancer Institute of New Jersey
Robert Wood Johnson Medical School and New Jersey Medical School of Rutgers University
New Brunswick, NJ, USA
Aaron M. Etra MD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
James L.M. Ferrara MD
Professor, Medicine, Hematology and Medical Oncology
Professor, Pediatrics
Professor, Oncological Sciences
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Philip Friedlander MD, PhD
Director of Melanoma Medical Oncology Program
Assistant Professor, Division of Hematology and Medical Oncology
Assistant Professor, Department of Dermatology
Icahn School of Medicine at Mount Sinai,
New York, NY, USA
Janice L. Gabrilove MD, PHD
Professor, Oncological Sciences
Professor, Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Matthew D. Galsky MD
Professor of Medicine
Icahn School of Medicine at Mount Sinai
Director, Genitourinary Medical Oncology
Tisch Cancer Institute
New York, NY, USA
Kalla A. Gervasio MD
Ophthalmology Resident
Department of Ophthalmology
Wills Eye Hospital
Philadelphia, PA, USA
Jorge E. Gomez MD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Jeanette Guziel MD
Hematology/Oncology
Kaiser Permanente
Southern California Permanente Medical Group
Woodland Hills, CA, USA
Lindsay Haines MD
Resident
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Adília Hormigo MD, PhD
Director, Neuro-Oncology at Mount Sinai and Mount Sinai Health System
Professor of Neurology, Medicine, and Neurosurgery
Icahn School of Medicine at Mount Sinai
The Tisch Cancer Institute
New York, NY, USA
Zishuo I. Hu MD, PhD
Professor
Icahn School of Medine at Mount Sinai
New York, NY, USA
Ran Huo MD
Department of Hospital Medicine
The Everett Clinic
Providence Regional Medical Center
Everett, WA, USA
Ilya Iofin MD
Chief of Orthopaedic Oncology Service
Department of Orthopaedic Surgery
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Luis Isola MD
Gerald J. Friedman Chair in Oncology
Professor of Medicine
Director, Cancer Clinical Programs, Mount Sinai Health System
Director, Bone Marrow and Stem Cell Transplantation Program, Tisch Cancer Institute
Director, Cancer Network, Mount Sinai Health Network
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Alla Keyzner MD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Michelle K. Kim MD
Professor
Center for Carcinoid and Neuroendocrine Tumors
Gastroenterology Division
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Anuja Kriplani MD, MPH
Jack Martin Division of Pediatric Hematology-Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Peter S. Kozuch MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Le Min Lee MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Siyang Leng MD
Instructor of Medicine
Division of Hematoloy/Oncology
Columbia University Irving Medical Center
New York, NY, USA
John E. Levine MD
Professor, Medicine, Hematology, and Medical Oncology
Professor, Pediatrics
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Bobby C. Liaw MD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Josep M. Llovet MD, PhD
Professor of Medicine
Division of Liver Diseases
Icahn School of Medicine at Mount Sinai
New York, NY, USA;
Liver Cancer Translational Research Laboratory, IDIBAPS, CIBEREHD
Hospital Clinic, Universitat de Barcelona;
Institució Catalana de Recerca i Estudis Avançats
Barcelona, Spain
Robert G. Maki MD, PhD, FACP
Northwell Cancer Institute and Cold Spring Harbor Laboratory
Long Island, NY, USA
Adriana K. Malone MD
Associate Professor
Tisch Cancer Institute Bone Marrow and Stem Cell Transplantation
Director, Hematology/Oncology and BMT Fellowship Programs
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Thomas U. Marron MD, PhD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Jacob A. Martin MD
Center for Carcinoid and Neuroendocrine Tumors
Gastroenterology Division
Icahn School of Medicine at Mount Sinai
New York, NY, USA
John Mascarenhas MD
Director, Adult Leukemia Program
Leader, Myeloproliferative Disorders Clinical Research Program
Associate Professor of Medicine
Tisch Cancer Institute, Division of Hematology/Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Reza Mehrazin MD
Assistant Professor
Department of Urology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Krzysztof Misiukiewicz MD
Associate Professor, Medicine, Hematology, and Medical Oncology
Assistant Professor, Otolaryngology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Melissa Nagelberg MS, RD
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Navya Nair MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Shyamala C. Navada MD, MSCR
Assistant Professor
Tisch Cancer Institute
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Scot A. Niglio MD
Fellow, Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Paula Occiano RD, CDN, CSO
Clinical Nutrition Coordinator
Tisch Cancer Institute
Icahn School of Medicine at Mount Sinai
New York, NY, USA
William K. Oh MD
Chief, Division of Hematology and Medical Oncology
Deputy Director, Tisch Cancer Institute
Professor of Medicine and Urology
Ezra M. Greenspan, MD Professor in Clinical Cancer Therapeutics
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Keren Osman MD
Bone Marrow Transplant Program
Mount Sinai Medical Center
New York, NY, USA
Doyun Park MD
Instructor, Department of Medicine
Blood and Bone Marrow Transplant Program
NYU School of Medicine
New York, NY, USA
Sofya Pintova MD
Division of Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Jamal Rahaman MD
Associate Clinical Professor
Obstetrics, Gynecology and Reproductive Science
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Meenakshi M. Rana MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Madhuri Rao MD
Assistant Professor
Division of Thoracic and Foregut Surgery
University of Minnesota
Minneapolis, MN, USA
Parth R. Rao MD
Associate, Cancer Institute
Geisinger Medical Center
Danville, PA, USA
Anne S. Renteria MD
Leader, Acute Lymphoblastic Leukemia
Research and Clinical Service
Bone Marrow Transplant & Adult Leukemia Program
Assistant Professor of Medicine
Tisch Cancer Institute
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Nicholas C. Rohs MD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Gagan Sahni MD, FACC, FACP
Associate Professor of Medicine
Director of Cardio-Oncology
Director of Cardiology Consult Services
Mount Sinai Cardiovascular Institute
New York, NY, USA
Bethann Scarborough MD
Associate Director of Ambulatory Services
Assistant Professor of Palliative Medicine
Brookdale Department of Geriatrics and Palliative Medicine
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Myron E. Schwartz MD
Professor of Surgery
Department of Surgery
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Eileen Scigliano MD
Associate Professor of Medicine
Icahn School of Medicine at Mount Sinai
Physician Lead, World Trade Center Cancer Program
Department of Environmental Medicine and Public Health
New York, NY, USA
Danielle S. Seiden MD
Icahn Scool of Medicine at Mount Sinai
New York, NY, USA
Ilan Shapira MD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Charles L. Shapiro MD, FASCO
Professor of Medicine, Division of Hematology and Oncology
Director of Translational Breast Cancer Research
Director of Cancer Survivorship
Icahn School of Medicine at Mount Sinai
Tisch Cancer Institute
New York, NY, USA
Aditya V. Shreenivas MD
Icahn Scool of Medicine at Mount Sinai
New York, NY, USA
Jonah Shulman MD
Assistant Professor
Division of Hematology and Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Lewis R. Silverman MD
Tisch Cancer Institute
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Cardinale B. Smith MD, PhD
Associate Professor of Medicine
Director of Quality for Cancer Services, Mount Sinai Health System
Division of Hematology/Medical Oncology and Brookdale Department of Geriatrics and Palliative Medicine
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Lori Spoozak MD, MHS, FACOG
Clinical Assistant Professor
Division of Gynecologic Oncology
Department of Obstetrics and Gynecology
Clinical Assistant Professor
Palliative Medicine Division
Department of Internal Medicine
University of Kansas School of Medicine
Kansas City, KS, USA
Amir Steinberg MD, FACP
Associate Professor of Medicine
Unit Director, Quality Director, Bone Marrow Transplant Program
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Jason W. Steinberg MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Akshay Sudhindra MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Max W. Sung MD
Associate Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Bachir Taouli MD
Translational and Molecular Imaging Institute
Department of Radiology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Amy Tiersten MD
Professor of Medicine
Clinical Director, Breast Medical Oncology at Mount Sinai Hospital
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Che-Kai Tsao MD
Associate Professor
Medicine, Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Mala Varma MD
Assistant Clinical Professor
Medicine, Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Rajwanth Veluswamy MD, MSCR
Assistant Professor
Medicine, Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Sangeetha Venugopal MD
Fellow, Hematology and Medical Oncology
Tisch Cancer Institute
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Augusto Villanueva MD, PhD
Assistant Professor of Medicine
Division of Liver Diseases
Division of Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Mathilde Wagner MD
Translational and Molecular Imaging Institute
Department of Radiology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Richard R.P. Warner MD
Professor Emeritus
Center for Carcinoid and Neuroendocrine Tumors
Gastroenterology Division
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Talia Wiesel PhD
Assistant Professor, Psychiatry
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Birte Wistinghausen MD
Children’s National Health System,
The George Washington University,
Washington, DC, USA
Andrea S. Wolf MD, MPH
Associate Professor
Department of Thoracic Surgery
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Albert Y. Wu MD, PhD, FACS
Department of Ophthalmology
Stanford University School of Medicine
Palo Alto, CA, USA
Ali John Zarrabi MD
Assistant Professor of Medicine
Associate Director, Outpatient Supportive Care, Emory Healthcare
Division of Hospital Medicine
Emory University School of Medicine
Atlanta, GA, USA
Brittney S. Zimmerman MD
Fellow, Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Now more than ever, immediacy in obtaining accurate and practical information is the coin of the realm in providing high quality patient care. The Mount Sinai Expert Guides series addresses this vital need by providing accurate, up-to-date guidance, written by experts in formats that are accessible in the patient care setting: websites, smartphone apps, and portable books. The Icahn School of Medicine, which was chartered in 1963, embodies a deep tradition of preeminence in clinical care and scholarship that was first shaped by the founding of the Mount Sinai Hospital in 1855. Today, the Mount Sinai Health System, comprised of seven hospitals anchored by the Icahn School of Medicine, is one of the largest health care systems in the United States, and is revolutionizing medicine through its embracing of transformative technologies for clinical diagnosis and treatment. The Mount Sinai Expert Guides series builds upon both this historical renown and contemporary excellence. Leading experts across a range of disciplines provide practical yet sage advice in a digestible format that is ideal for trainees, mid-level providers, and practicing physicians. Few medical centers in the United States could offer this type of breadth while relying exclusively on its own physicians, yet here no compromises were required in offering a truly unique series that is sure to become embedded within the key resources of busy providers. In producing this series, the editors and authors are fortunate to have an equally dynamic and forward-viewing partner in Wiley Blackwell, which together ensures that health care professionals will benefit from a unique, first-class effort that will advance the care of their patients.
Scott Friedman MD
Series Editor
Dean for Therapeutic Discovery
Fishberg Professor and Chief, Division of Liver Diseases
Icahn School of Medicine at Mount Sinai
New York, NY, USA
In an era of innumerable sources of information yet ever increasing and competing demands on clinicians’ time, it can be difficult to come up to speed quickly, yet reliably, on the rapidly evolving management of hematology and oncology patients. This is certainly true for those in training but also for busy practitioners treating a diversity of patients. In this Expert Guide we strive to provide concise summaries – using bullet points, tables, and figures in lieu of verbose texts, written by renowned disease experts at the Icahn School of Medicine at Mount Sinai, New York. The sections are divided into oncology, hematology, bone marrow transplant, and, importantly, an entire section on the multidisciplinary care of cancer patients. The content can be viewed in conventional print form or, for those preferring digital access, via the internet or a smartphone app. For those looking for more in-depth information, lists of further reading are also provided.
William K. Oh, MD
Chief, Division of Hematology and Medical Oncology
Deputy Director, The Tisch Cancer Institute
Professor of Medicine and Urology
Ezra M. Greenspan, MD Professor in Clinical Cancer Therapeutics
Icahn School of Medicine at Mount Sinai
New York, NY, USA
Ajai Chari, MD
Associate Professor of Medicine
Director Clinical Research, Multiple Myeloma Program
Associate Medical Director, Tisch Cancer Institute Clinical Trials Office
Icahn School of Medicine at Mount Sinai
New York, NY, USA