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MOUNT SINAI EXPERT GUIDES

 

Oncology

EDITED BY

William K. Oh, MD

Chief, Division of Hematology and Medical Oncology
Deputy Director, The Tisch Cancer Institute
Professor of Medicine and Urology
Ezra M. Greenspan, MD Professor in Clinical Cancer Therapeutics
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Ajai Chari, MD

Associate Professor of Medicine
Director Clinical Research, Multiple Myeloma Program
Associate Medical Director, Tisch Cancer Institute Clinical Trials Office
Icahn School of Medicine at Mount Sinai
New York, NY, USA




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Contributors

Raquela Adelsberg, MS, RD, CDN
Clinical Nutrition Coordinator
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Celina Ang MD
Associate Professor
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Kenneth L. Angelino MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Daniel Aruch MD
Oncologist
Virginia Oncologist Associates
Virginia Beach, VA, USA

Kevin Barley MD
Hematologist
Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Meredith K. Bartelstein MD
Fellow, Orthopedic Oncology
Memorial Sloan Kettering Cancer Center
New York, NY, USA

Surabhi Batra MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Ann Marie Beddoe MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Adam F. Binder MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Joshua D. Brody
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Rebecca M. Brown MD, PhD
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Corazon B. Cajulis DNP, RN, ANP-BC
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Ajai Chari MD
Associate Professor of Medicine
Director Clinical Research, Multiple Myeloma Program
Associate Medical Director, Tisch Cancer Institute Clinical Trials Office
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Carmel J. Cohen MD
Professor Emeritus
Obstetrics, Gynecology and Reproductive Science
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Seth M. Cohen MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Idoia Corcuera-Solano MD
Translational and Molecular Imaging Institute
Department of Radiology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Caroline Cromwell MD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Bruce E. Culliney MD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Jaclyn C. Davis MD
Clinical Development Medical Director
Novartis Pharmaceuticals Corporation
East Hanover, NJ, USA

Peter Dottino MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Ashley J. D'Silva MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Ronald D. Ennis MD
Professor and Vice Chair of Network Integration and Quality
Department of Radiation Oncology
Cancer Institute of New Jersey
Robert Wood Johnson Medical School and New Jersey Medical School of Rutgers University
New Brunswick, NJ, USA

Aaron M. Etra MD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

James L.M. Ferrara MD
Professor, Medicine, Hematology and Medical Oncology
Professor, Pediatrics
Professor, Oncological Sciences
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Philip Friedlander MD, PhD
Director of Melanoma Medical Oncology Program
Assistant Professor, Division of Hematology and Medical Oncology
Assistant Professor, Department of Dermatology
Icahn School of Medicine at Mount Sinai,
New York, NY, USA

Janice L. Gabrilove MD, PHD
Professor, Oncological Sciences
Professor, Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Matthew D. Galsky MD
Professor of Medicine
Icahn School of Medicine at Mount Sinai
Director, Genitourinary Medical Oncology
Tisch Cancer Institute
New York, NY, USA

Kalla A. Gervasio MD
Ophthalmology Resident
Department of Ophthalmology
Wills Eye Hospital
Philadelphia, PA, USA

Jorge E. Gomez MD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Jeanette Guziel MD
Hematology/Oncology
Kaiser Permanente
Southern California Permanente Medical Group
Woodland Hills, CA, USA

Lindsay Haines MD
Resident
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Adília Hormigo MD, PhD
Director, Neuro-Oncology at Mount Sinai and Mount Sinai Health System
Professor of Neurology, Medicine, and Neurosurgery
Icahn School of Medicine at Mount Sinai
The Tisch Cancer Institute
New York, NY, USA

Zishuo I. Hu MD, PhD
Professor
Icahn School of Medine at Mount Sinai
New York, NY, USA

Ran Huo MD
Department of Hospital Medicine
The Everett Clinic
Providence Regional Medical Center
Everett, WA, USA

Ilya Iofin MD
Chief of Orthopaedic Oncology Service
Department of Orthopaedic Surgery
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Luis Isola MD
Gerald J. Friedman Chair in Oncology
Professor of Medicine
Director, Cancer Clinical Programs, Mount Sinai Health System
Director, Bone Marrow and Stem Cell Transplantation Program, Tisch Cancer Institute
Director, Cancer Network, Mount Sinai Health Network
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Alla Keyzner MD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Michelle K. Kim MD
Professor
Center for Carcinoid and Neuroendocrine Tumors
Gastroenterology Division
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Anuja Kriplani MD, MPH
Jack Martin Division of Pediatric Hematology-Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Peter S. Kozuch MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Le Min Lee MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Siyang Leng MD
Instructor of Medicine
Division of Hematoloy/Oncology
Columbia University Irving Medical Center
New York, NY, USA

John E. Levine MD
Professor, Medicine, Hematology, and Medical Oncology
Professor, Pediatrics
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Bobby C. Liaw MD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Josep M. Llovet MD, PhD
Professor of Medicine
Division of Liver Diseases
Icahn School of Medicine at Mount Sinai
New York, NY, USA;
Liver Cancer Translational Research Laboratory, IDIBAPS, CIBEREHD
Hospital Clinic, Universitat de Barcelona;
Institució Catalana de Recerca i Estudis Avançats
Barcelona, Spain

Robert G. Maki MD, PhD, FACP
Northwell Cancer Institute and Cold Spring Harbor Laboratory
Long Island, NY, USA

Adriana K. Malone MD
Associate Professor
Tisch Cancer Institute Bone Marrow and Stem Cell Transplantation
Director, Hematology/Oncology and BMT Fellowship Programs
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Thomas U. Marron MD, PhD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Jacob A. Martin MD
Center for Carcinoid and Neuroendocrine Tumors
Gastroenterology Division
Icahn School of Medicine at Mount Sinai
New York, NY, USA

John Mascarenhas MD
Director, Adult Leukemia Program
Leader, Myeloproliferative Disorders Clinical Research Program
Associate Professor of Medicine
Tisch Cancer Institute, Division of Hematology/Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Reza Mehrazin MD
Assistant Professor
Department of Urology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Krzysztof Misiukiewicz MD
Associate Professor, Medicine, Hematology, and Medical Oncology
Assistant Professor, Otolaryngology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Melissa Nagelberg MS, RD
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Navya Nair MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Shyamala C. Navada MD, MSCR
Assistant Professor
Tisch Cancer Institute
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Scot A. Niglio MD
Fellow, Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Paula Occiano RD, CDN, CSO
Clinical Nutrition Coordinator
Tisch Cancer Institute
Icahn School of Medicine at Mount Sinai
New York, NY, USA

William K. Oh MD
Chief, Division of Hematology and Medical Oncology
Deputy Director, Tisch Cancer Institute
Professor of Medicine and Urology
Ezra M. Greenspan, MD Professor in Clinical Cancer Therapeutics
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Keren Osman MD
Bone Marrow Transplant Program
Mount Sinai Medical Center
New York, NY, USA

Doyun Park MD
Instructor, Department of Medicine
Blood and Bone Marrow Transplant Program
NYU School of Medicine
New York, NY, USA

Sofya Pintova MD
Division of Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Jamal Rahaman MD
Associate Clinical Professor
Obstetrics, Gynecology and Reproductive Science
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Meenakshi M. Rana MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Madhuri Rao MD
Assistant Professor
Division of Thoracic and Foregut Surgery
University of Minnesota
Minneapolis, MN, USA

Parth R. Rao MD
Associate, Cancer Institute
Geisinger Medical Center
Danville, PA, USA

Anne S. Renteria MD
Leader, Acute Lymphoblastic Leukemia
Research and Clinical Service
Bone Marrow Transplant & Adult Leukemia Program
Assistant Professor of Medicine
Tisch Cancer Institute
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Nicholas C. Rohs MD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Gagan Sahni MD, FACC, FACP
Associate Professor of Medicine
Director of Cardio-Oncology
Director of Cardiology Consult Services
Mount Sinai Cardiovascular Institute
New York, NY, USA

Bethann Scarborough MD
Associate Director of Ambulatory Services
Assistant Professor of Palliative Medicine
Brookdale Department of Geriatrics and Palliative Medicine
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Myron E. Schwartz MD
Professor of Surgery
Department of Surgery
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Eileen Scigliano MD
Associate Professor of Medicine
Icahn School of Medicine at Mount Sinai
Physician Lead, World Trade Center Cancer Program
Department of Environmental Medicine and Public Health
New York, NY, USA

Danielle S. Seiden MD
Icahn Scool of Medicine at Mount Sinai
New York, NY, USA

Ilan Shapira MD
Assistant Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Charles L. Shapiro MD, FASCO
Professor of Medicine, Division of Hematology and Oncology
Director of Translational Breast Cancer Research
Director of Cancer Survivorship
Icahn School of Medicine at Mount Sinai
Tisch Cancer Institute
New York, NY, USA

Aditya V. Shreenivas MD
Icahn Scool of Medicine at Mount Sinai
New York, NY, USA

Jonah Shulman MD
Assistant Professor
Division of Hematology and Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Lewis R. Silverman MD
Tisch Cancer Institute
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Cardinale B. Smith MD, PhD
Associate Professor of Medicine
Director of Quality for Cancer Services, Mount Sinai Health System
Division of Hematology/Medical Oncology and Brookdale Department of Geriatrics and Palliative Medicine
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Lori Spoozak MD, MHS, FACOG
Clinical Assistant Professor
Division of Gynecologic Oncology
Department of Obstetrics and Gynecology
Clinical Assistant Professor
Palliative Medicine Division
Department of Internal Medicine
University of Kansas School of Medicine
Kansas City, KS, USA

Amir Steinberg MD, FACP
Associate Professor of Medicine
Unit Director, Quality Director, Bone Marrow Transplant Program
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Jason W. Steinberg MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Akshay Sudhindra MD
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Max W. Sung MD
Associate Professor
Medicine, Hematology, and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Bachir Taouli MD
Translational and Molecular Imaging Institute
Department of Radiology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Amy Tiersten MD
Professor of Medicine
Clinical Director, Breast Medical Oncology at Mount Sinai Hospital
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Che-Kai Tsao MD
Associate Professor
Medicine, Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Mala Varma MD
Assistant Clinical Professor
Medicine, Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Rajwanth Veluswamy MD, MSCR
Assistant Professor
Medicine, Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Sangeetha Venugopal MD
Fellow, Hematology and Medical Oncology
Tisch Cancer Institute
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Augusto Villanueva MD, PhD
Assistant Professor of Medicine
Division of Liver Diseases
Division of Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Mathilde Wagner MD
Translational and Molecular Imaging Institute
Department of Radiology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Richard R.P. Warner MD
Professor Emeritus
Center for Carcinoid and Neuroendocrine Tumors
Gastroenterology Division
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Talia Wiesel PhD
Assistant Professor, Psychiatry
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Birte Wistinghausen MD
Children’s National Health System,
The George Washington University,
Washington, DC, USA

Andrea S. Wolf MD, MPH
Associate Professor
Department of Thoracic Surgery
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Albert Y. Wu MD, PhD, FACS
Department of Ophthalmology
Stanford University School of Medicine
Palo Alto, CA, USA

Ali John Zarrabi MD
Assistant Professor of Medicine
Associate Director, Outpatient Supportive Care, Emory Healthcare
Division of Hospital Medicine
Emory University School of Medicine
Atlanta, GA, USA

Brittney S. Zimmerman MD
Fellow, Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, NY, USA

Series Foreword

Now more than ever, immediacy in obtaining accurate and practical information is the coin of the realm in providing high quality patient care. The Mount Sinai Expert Guides series addresses this vital need by providing accurate, up-to-date guidance, written by experts in formats that are accessible in the patient care setting: websites, smartphone apps, and portable books. The Icahn School of Medicine, which was chartered in 1963, embodies a deep tradition of preeminence in clinical care and scholarship that was first shaped by the founding of the Mount Sinai Hospital in 1855. Today, the Mount Sinai Health System, comprised of seven hospitals anchored by the Icahn School of Medicine, is one of the largest health care systems in the United States, and is revolutionizing medicine through its embracing of transformative technologies for clinical diagnosis and treatment. The Mount Sinai Expert Guides series builds upon both this historical renown and contemporary excellence. Leading experts across a range of disciplines provide practical yet sage advice in a digestible format that is ideal for trainees, mid-level providers, and practicing physicians. Few medical centers in the United States could offer this type of breadth while relying exclusively on its own physicians, yet here no compromises were required in offering a truly unique series that is sure to become embedded within the key resources of busy providers. In producing this series, the editors and authors are fortunate to have an equally dynamic and forward-viewing partner in Wiley Blackwell, which together ensures that health care professionals will benefit from a unique, first-class effort that will advance the care of their patients.

Scott Friedman MD

Series Editor

Dean for Therapeutic Discovery

Fishberg Professor and Chief, Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Preface

In an era of innumerable sources of information yet ever increasing and competing demands on clinicians’ time, it can be difficult to come up to speed quickly, yet reliably, on the rapidly evolving management of hematology and oncology patients. This is certainly true for those in training but also for busy practitioners treating a diversity of patients. In this Expert Guide we strive to provide concise summaries – using bullet points, tables, and figures in lieu of verbose texts, written by renowned disease experts at the Icahn School of Medicine at Mount Sinai, New York. The sections are divided into oncology, hematology, bone marrow transplant, and, importantly, an entire section on the multidisciplinary care of cancer patients. The content can be viewed in conventional print form or, for those preferring digital access, via the internet or a smartphone app. For those looking for more in-depth information, lists of further reading are also provided.

William K. Oh, MD

Chief, Division of Hematology and Medical Oncology

Deputy Director, The Tisch Cancer Institute

Professor of Medicine and Urology

Ezra M. Greenspan, MD Professor in Clinical Cancer Therapeutics

Icahn School of Medicine at Mount Sinai

New York, NY, USA


Ajai Chari, MD

Associate Professor of Medicine

Director Clinical Research, Multiple Myeloma Program

Associate Medical Director, Tisch Cancer Institute Clinical Trials Office

Icahn School of Medicine at Mount Sinai

New York, NY, USA